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The following is a list of articles on cyclotides published by our group.

Journal Articles

  • Saether O, Craik D J, Campbell I D, Sletten K, Juul J, Norman D G: Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1. Biochemistry, (1995) 34, 4147-4158.
  • Daly N L, Koltay A, Gustafson K R, Boyd M R, Casa-Finet J R, Craik D J: Solution structure by NMR of circulin A: a macrocyclic peptide having anti-HIV activity. J Mol Biol (1999) 285, 333-345.
  • Daly N L, Love S, Alewood P F, Craik D J: Chemical synthesis and folding pathways of large cyclic polypeptides: Studies of the cystine knot polypeptide kalata B1. Biochemistry (1999) 38, 10606-10614.
  • Craik D J: Applications of NMR in drug design: Structure-activity relationships in disulfide-rich peptides. Protein and Peptide Letters (1999) 6, 341-350.
  • Craik D J, Daly N L, Bond, T, Waine C: Plant cyclotides - a unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. J Mol Biol (1999) 294, 1327-1336.
  • Daly N L, Craik D J: Acyclic permutants of naturally occurring cyclic proteins: Characterization of cystine knot and ?-sheet formation in the macrocyclic polypeptide Kalata B1. J Biol Chem (2000) 275, 19068-19075.
  • Craik D J, Daly N L, Waine C: The cystine knot motif in toxins and implications for drug design. Toxicon (2001) 39, 43-60.
  • Craik D J: Plant cyclotides: Circular, knotted peptide toxins. Toxicon(2001) 39, 1809-1813.
  • Felizmenio-Quimio M E, Daly N L, Craik D J: Circular proteins in plants: Solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis. J. Biol Chem. (2001) 276, 22875-22882.
  • Jennings C, West J, Waine C, Craik D, Anderson M: Biosynthesis and insecticidal properties of plant cyclotides - the cyclic knotted proteins from O. affinis. PNAS (2001) 98, 10614-10619.
  • Craik D J, Anderson M, Barry D, Daly N L, Jennings C, Mulvenna J: Discovery and structures of the cyclotides: Circular peptides from plants. Letters in Peptide Science (in press).

Reviews

  • Trabi M, Craik D J: Circular proteins - no end in sight. Trends in Biochemical Sciences (2002) 27, 132-138.
  • Craik D J, Simonsen S, Daly N L: The cyclotides: Novel macrocyclic peptides as scaffolds in drug design. Current Opinion in Drug Discovery & Development (2002, in press).
  • Craik D J, Daly N L, Plan M, Salim A, Sandø L: Structure and function of plant toxins. Journal of Toxicology: Toxin Reviews (in press).

Other articles in the literature that discuss cyclotides: